Prospective event-driven unblinded randomized multicenter trial of at least 4, subjects enrolled in at least 25 international centers. Patients will be randomized in a fashion between the two groups. Permuted block randomization with random blocks stratified by the center and the type of second arterial graft will be used to provide treatment distribution in equal proportion.
A prospective randomized clinical trial aimed at evaluating the efficacy of a new method for the prevention of postoperative atrial fibrillation: Posterior left pericardiotomy for the prevention of postoperative atrial fibrillation after cardiac surgery.
Secondary Objectives: To determine the incidence of post-operative pericardial or pleural effusions after cardiac surgery when posterior pericardiotomy is performed.
Primary Objective: a prospective, multicenter, open-label, randomized, active controlled clinical trial to determine if patients with an On-X aortic valve, alone or as an On-X Ascending Aortic Prosthesis, can be maintained safely and effectively on apixaban. The primary efficacy outcome is a composite rate of valve thrombosis and valve-related thromboembolism, which will be used for co-primary analyses.
The first co-primary analysis will determine whether apixaban is non-inferior to warfarin International Normalized Ratio [INR] target range 2. The second co-primary analysis will compare the composite rate for apixaban-treated participants to updated objective performance criterion for FDA-approved mechanical heart valves in the aortic position.
Each participants will be followed for at least 2 years and each randomized arm will achieve at least patient-years. Secondary Objectives : CT Sub-Study: The purpose of the study is to investigate the prevalence of the imaging abnormality.
Primary Objective: To evaluate the safety and effectiveness of the Tendyne Mitral Valve System for the treatment of patients with symptomatic, moderate-tosevere or severe mitral regurgitation or for patients with symptomatic mitral valve disease due to severe mitral annular calcification.
Principal Investigator: Stephanie L. Primary Objective: The use of wearable personal fitness monitors WPFMs in risk assessment and as recuperation aids in minimally invasive cardiac surgery e. Hence, this study may potentially help to create new paradigms for cardiac surgery patient selection and postoperative recovery.
Primary Objective: This clinical trial is for men and women who are diagnosed with severe aortic stenosis and are at intermediate-risk for traditional open-heart surgery for aortic valve replacement.
Filter By Clear all Advanced. Male only 1 Female only 6 Any Reset Apply. I am looking for. I am looking for heparin. I am looking for levosimendan. I am looking for antibiotics. I am looking for vasopressor. I am looking for fibrinogen. I am looking for sevoflurane. I am looking for propofol. I am looking for cytokines. I am looking for amiodarone. I am looking for opioid. I am looking for dexmedetomidine. I am looking for tranexamic acid.
I am looking for blood lactate. I am looking for antiarrhythmic drugs. The purpose of this study is to learn more about early and late outcomes in patients after mitral valve repair. Researchers in the Division of Cardiovascular Surgery at Mayo Clinic are developing a new research resource called the "Cardiovascular Surgery Biobank" hereafter referred to as the "Biobank".
Participants in the Biobank allow investigators at the Mayo Clinic to obtain diseased tissue that is removed during cardiovascular surgery, and allow access to medical records for research now and in the future. The Biobank serves as a resource for researchers in cardiovascular disease; instead of having to wait for months or years for tissue to be accumulated, researchers can use samples from the Biobank that were normally removed as a part of your surgical procedure.
All patients in this clinical trial will receive L-CsA in addition to Standard of Care, regardless of randomization arm in prior trials.
Currently, warfarin is the only approved anticoagulation for patients with mechanical valves. The purpose of this study is to assess the clinical utility of surveillance using HeartCare testing services, in association with clinical care of heart transplant recipients.
The purpose of this study is to examine the effects of a health coaching intervention on the stress and burden of caregivers of patients awaiting heart or lung transplant. Hypotheses: Caregivers will have traits and behaviors pre-transplant that will predict caregiver readiness, quality of life, and transplant recipient outcomes.
Specifically, thoracic pre-transplant caregivers report stress, symptoms of anxiety or depression, and perceive high caregiver burden. These factors may be amenable to pre-transplant intervention to improve overall patient and caregiver outcomes. Aims, purpose, or objectives: We will conduct a pilot trial to test whether caregivers of heart and lung transplant candidates who receive wellness coaching will experience improvement in caregiver-related distress.
We will also explore the relationship between caregiving and factors such as uncertainty, resilience, stress level, and affect.
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